25th PGC学术预告 | 大会报告人郑丙莲
报告题目
Intronic lariat RNA turnover in plants
报告时间
8.21 14:30 - 14:50
个人介绍
郑丙莲
复旦大学教授
主要研究方向
植物RNA生物学
以拟南芥和大豆为研究对象,探索不同种类的非编码RNA,尤其是套索RNA、转座子RNA和小RNA,如何产生、如何发挥作用以及在植物生殖发育中发挥何种作用。
报告摘要
Lariat RNAs are formed from introns during pre-mRNA splicing, after which they are degraded by the debranching enzyme DBR1. Impairment of DBR1 leads to developmental arrest, yet the mechanism remains unclear. Here, we show that debranching of lariat RNA prevents production of 21- and 22-nt lariat-derived siRNAs (lasiRNA), which causes the burst of exonic siRNAs, thereby safeguarding development and defense response. LasiRNA biogenesis relies on RNA-dependent RNA polymerases (RDRs) and Dicer-like proteins (DCLs). Upon pathogen infection, DBR1-dependent lariat RNA removal is accelerated and these lariat RNAs are processed by DCL4 and DCL2 into siRNAs, particularly targeting immunity genes, ultimately disrupting plant defense responses. Collectively, DBR1-dependent lariat RNA removal serves as a p
2026-08-14