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25th PGC学术预告 | 大会报告人陈学伟
报告题目
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence
个人介绍
陈学伟
四川农业大学教授
主要研究方向
1. 作物抗性资源发掘与创制
2. 抗病机理解析及抗病育种
3. 病原菌致病机理解析及新农药开发
报告摘要
Plants and animals respond to pathogens using pattern-recognition receptor and Nod-like receptor (NLR) proteins. Pathogens often utilize protein
effectors to suppress host immunity for successful infection, but other types of effectors exist although less studied. Here, we report an RNA-RNA
recognition mechanism between pathogens and hosts mediated by a Conserved, Regulatory RNA-Encoding DNA (CRRED) region that separately
produces two complementary regulatory RNAs. Specifically, a long non-coding RNA (lncRNA) transcribed from a CRRED region in pathogen Magnaporthe
oryzae enters host rice cells and sequesters a complementary microRNA (miRNA), derived from a separate host CRRED region, to subvert host immunity.
Conversely, the microRNA derived from host rice CRRED promotes disease resistance by repressing expression of PKR1 gene encoding a negative regulator
of host immunity. Sequestration of the host miRNA by the fungal lncRNA releases PKR1 expression to facilitate fungal infection. We then discover that this
CRRED sequence is likely widely present among life kingdom to mediate interactions between pathogens and plant hosts. Furthermore, our findings
provide an approach for effective disease control using CRRED-derived miRNAs.
最新研究进展
Nature：在作物与病原菌“对话机制”研究上取得新突破
5月20日，西南作物基因资源发掘与利用国家重点实验室陈学伟领衔的团队，在国际学术期刊《自然》(Nature)上，发表了题为A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence(病原菌分泌lncRNA进入水稻劫持寄主 miRNA 以调控致病性)的研究论文。该研究揭示了病原菌与寄主之间非编码RNA介导的跨界对话机制，为作物的广谱抗病育种与病害绿色防控提供了新策略。
第二十五届全国植物基因组学大会将于2026年8月19日–22日在内蒙古自治区呼和浩特市召开，大会同期将举办Plant Innovation 首届编辑委员会会议及植物遗传与基因组学专业委员会工作会议，诚邀国内同行参加!大会信息详见官网https://plantgenomics.tri-think.cn
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