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Heat-triggered saturated phosphatidylcholines flipping stabilizes plasma membrane fluidity
个人介绍
钦鹏
四川农业大学教授
主要研究方向
1. 水稻种质资源评价、创新和遗传改良
2. 耐高温位点挖掘、机理解析与育种应用
报告摘要
Cells must rapidly counteract heat-stress-induced hyperfluidization of the plasma membrane (PM) to prevent membrane damage, yet how cells achieve such early protection remains unknown. Here, we show that the P4-ATPase OsALA5. together with its β-subunit OsALIS2. mediates a heat-responsive flipping of saturated phosphatidylcholines (PCs) that rapidly stabilizes PM fluidity in rice. Using leaflet-resolved lipidomics and complementary transport assays, we demonstrate that heat exposure induces a minute-scale shift in OsALA5 transport activity that leads to selective enrichment of saturated PCs in the cytoplasmic PM leaflet. This OsALA5-mediated saturated PC flipping prevents PM hyperfluidization upon heat stress, thus mitigating ion leakage and cell death. Our analyses of OsALA5 orthologs in Arabidopsis and yeast support functional conservation of a rapid heat-associated response within a subset of PM-localized, PC-transporting P4-ATPases. We identified a rare haplotype of OsALA5 that confers both heat tolerance and yield stability in multi-year, multi-location field trials. Thus, beyond discovering this P4-ATPase-mediated flipping of saturated PCs in response to heat stress and providing genetic resources to advance breeding of heat-tolerant crops, our study reveals how cells are able to prevent heat-stress-driven PM hyperfluidization ahead of the previously known mechanisms of transcription-dependent protective lipid remodeling.
最新研究进展
Nature：在水稻耐高温研究上取得重要突破
7月1日，四川农业大学水稻研究所钦鹏、李仕贵团队联合中国科学技术大学生命科学与医学部向成斌、孙林峰团队，在国际学术期刊《自然》(Nature)发表题为“Heat-triggered phospholipid flipping stabilizes plasma membrane fluidity(热触发的磷脂翻转稳定质膜流动性)”的研究论文。该研究揭示了水稻通过磷脂翻转快速稳定细胞质膜流动性的新机制，为作物耐热分子设计育种提供了新的理论依据和优异基因资源。
第二十五届全国植物基因组学大会将于2026年8月19日–22日在内蒙古自治区呼和浩特市召开，大会同期将举办Plant Innovation 首届编辑委员会会议及植物遗传与基因组学专业委员会工作会议，诚邀国内同行参加!大会信息详见官网https://plantgenomics.tri-think.cn
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